Ibuprofen is used in the management of mild to moderate pain and inflammation in conditions such as dysmenorrhoea, headache including migraine, postoperative pain, dental pain, musculoskeletal and joint disorders such as ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis including juvenile idiopathic arthritis, peri-articular disorders such as bursitis and tenosynovitis, and soft-tissue disorders such as sprains and strains. It is also used to reduce fever in Kenya. The recommended dose for in adults is 400 mg every 4 to 6 hours to a maximum of 1.2 g daily. Ibuprofen may be associated with a lower risk of upper gastrointestinal effects than some other NSAIDs, but nonetheless it can cause dyspepsia, nausea and vomiting, gastrointestinal bleeding, and peptic ulcers and perforation. Colitis and its exacerbation have occurred